In a nutshell, a systematic review is a secondary study from a collection of primary studies (original research) that pertain to a specific research question. Those primary studies have been analyzed, examined, appraised, and evaluated for the highest level of evidence and quality of methodology, in order to provide the best answer to a research question.
The methods and/or protocol of conducting a systematic review are clear, understandable, rigorous and transparent. In a systematic review, you should see:
Additional Definitions:
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Systematic reviews are often confused with review articles. This type of publication are often called narrative reviews or literature reviews.
Literature reviews (or narrative reviews or review articles) are valuable and help to build one's knowledge base on a topic. However, they are quite different from systematic reviews.
1. Aiman W, Ali MA, Jumean S, et al. BRAF Inhibitors in BRAF-Mutated Colorectal Cancer: A Systematic Review. J Clin Med. Dec 25 2023;13(1)doi:10.3390/jcm13010113
2. Covell MM, Roy JM, Rumalla K, et al. The Limited Utility of the Hospital Frailty Risk Score as a Frailty Assessment Tool in Neurosurgery: A Systematic Review. Neurosurgery. Feb 1 2024;94(2):251-262. doi:10.1227/neu.0000000000002668
3. Drivas E, Gachabayov M, Kajmolli A, Stadlan Z, Felsenreich DM, Castaldi M. Quilting Suture Technique After Mastectomy: A Meta-Analysis. Am Surg. Dec 2023;89(12):6045-6052. doi:10.1177/00031348231173995
4. Faden J, Citrome L. A systematic review of clozapine for aggression and violence in patients with schizophrenia or schizoaffective disorder. Schizophr Res. Jan 29 2024;doi:10.1016/j.schres.2023.11.008
5. Gachabayov M, Kajmolli A, Quintero L, et al. Inadvertent laparoscopic lavage of perforated colon cancer: a systematic review. Langenbecks Arch Surg. Jan 10 2024;409(1):35. doi:10.1007/s00423-023-03224-5
6. Ingrassia JP, Maqsood MH, Gelfand JM, et al. Cardiovascular and Venous Thromboembolic Risk With JAK Inhibitors in Immune-Mediated Inflammatory Skin Diseases: A Systematic Review and Meta-Analysis. JAMA Dermatol. Jan 1 2024;160(1):28-36. doi:10.1001/jamadermatol.2023.4090
7. Ligi D, Della Franca C, Notarte KI, et al. Platelet distribution width (PDW) as a significant correlate of COVID-19 infection severity and mortality. Clin Chem Lab Med. Feb 26 2024;62(3):385-395. doi:10.1515/cclm-2023-0625
8. Nduma BN, Al-Ajlouni YA, Njei B. The Application of Artificial Intelligence (AI)-Based Ultrasound for the Diagnosis of Fatty Liver Disease: A Systematic Review. Cureus. Dec 2023;15(12):e50601. doi:10.7759/cureus.50601
9. Sreenivasan J, Reddy RK, Jamil Y, et al. Intravascular Imaging-Guided Versus Angiography-Guided Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis of Randomized Trials. J Am Heart Assoc. Jan 16 2024;13(2):e031111. doi:10.1161/jaha.123.031111
10. Stifani BM, Lavelanet AF. Reversal of medication abortion with progesterone: a systematic review. BMJ Sex Reprod Health. Jan 9 2024;50(1):43-52. doi:10.1136/bmjsrh-2023-201875
NOTE: Linking to the Cochrane Databases and PubMed through the Health Sciences Library ensures that you have access to the full text of systematic reviews and articles when available.